Poly(ADP‐ribose) polymerases (PARPs) are a family of enzymes that play a crucial role in maintaining genomic integrity by detecting DNA damage and facilitating its repair. By catalysing the covalent ...

Deinococcus radiodurans is renowned for its extraordinary resistance to ionising radiation and other environmental stresses. This bacterium employs a combination of passive and active mechanisms to ...

Cardiff University researchers discovered how a particularly severe type of DNA damage occurs, giving fresh insight into mutation mechanisms that contribute to cancer and inherited genetic diseases.

A study explains how broken DNA during cell division can trigger chromoanasynthesis when two repair pathways combine, causing ...

More than 200 metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found sitting directly on top of human DNA, according to a study published in ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

A team of international researchers at the University of Oxford (Oxford) and Nanyang Technological University, Singapore (NTU Singapore), has discovered a new process for repairing damaged DNA that is ...

Researchers at Memorial Sloan Kettering Cancer Center (MSK) have made an important discovery about how genetic mutations in ...

Three biochemical steps of the non-homologous DNA end-joining (NHEJ) process. This figure outlines the key stages of the NHEJ repair mechanism following DNA double-strand breaks. The process can be ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe University Frankfurt, part of the Rhine-Main University ...

A major advance in cell biology has revealed how our cells safeguard their genetic material during one of the most vulnerable moments in their life cycle. The study identifies a specific protein ...