Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

Cryo-electron microscopy (cryo-EM) imaging of DNA replication origin activation explains the role of Mcm10, a minichromosome maintenance (MCM) protein homolog, during initiation. Mcm10 acts as a wedge ...

Error-free duplication of genetic information and its transmission across cellular generations is an essential prerequisite for the healthy life of any organism. Deoxyribonucleic acid (DNA), a carrier ...