ascopubs.org

Exome Sequencing of Paired Colorectal Carcinomas and Synchronous Liver Metastases for Prognosis and Therapy Prediction

TP53 Gain-of-Function and Non–Gain-of-Function Mutations Are Associated With Differential Prognosis in Advanced Pancreatic Ductal Adenocarcinoma The study used whole-exome sequencing of tumor sample ...
Nature

DNA and RNA-based amplicon sequencing of paired supragingival and dentin lesion plaque in children with severe early childhood caries

To investigate the relationship between active bacterial strains within deep dentin lesions and SP within S-ECC patients, we designed and implemented a cross-sectional study that recruited 13 children ...
Nature

Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data

Therapeutic antibodies are rapidly emerging as the most successful class of biotherapeutics, with their yearly number of regulatory approvals reaching the same levels as the small molecule drugs 1.
ascopubs.org

Solving Missing Heritability in Patients With Familial Adenomatous Polyposis With DNA-RNA Paired Testing

Patients with germline pathogenic variants (PVs) in APC develop tens (attenuated familial adenomatous polyposis [AFAP]) to innumerable (classic FAP) adenomatous polyps in their colon and are at ...
GEN

Frontiers in Next-Generation Sequencing

High-throughput, next-generation sequencing instruments have dramatically accelerated the sequencing of genomes. The growth of this technology serves as an important milepost for the biomedical ...