In just a few decades, DNA sequencing technologies evolved from slow, manual processes to rapid, automated ones, making ...

Signal-to-noise. A high signal-to-noise ratio is important for achieving single-nucleotide resolution in sequencing. A lower current noise level can be attained by mutating a lysine residue in a ...

To understand more fully the role of RNA and its modifications in living systems, researchers will need robust, reproducible, and accessible tools and techniques capable of identifying all RNA ...

Small RNA sequencing encompasses a suite of high-throughput approaches designed to capture and quantify populations of short non-coding RNAs, principally microRNAs, small interfering RNAs and ...

The cause of rare diseases is increasingly being detected through genome sequencing, which involves reading the entire human DNA by first breaking it into small pieces—short reads. Christian Gilissen, ...

Our food and our bodies are full of tiny protein fragments called peptides. These small chains of amino acids act as biological messengers, influencing processes ranging from sensory perception to ...

Sequencing has rapidly expanded researchers’ understanding of basic biological processes in both health and disease. As sequencing technology becomes ubiquitous, scientists take their research to new ...

Long-read sequencing technologies analyze long, continuous stretches of DNA. These methods have the potential to improve researchers' ability to detect complex genetic alterations in cancer genomes.

Whole-genome sequencing of microbial isolates provides valuable information for public health, clinical microbiology research, food safety and microbial ecology. Nanopore sequencing offers distinct ...

While non-invasive prenatal testing (NIPT) has revolutionised prenatal diagnostics by allowing the detection of a number of ...

Every cancer carries a unique genetic fingerprint: variations in DNA known as “somatic variants” that occur in tumor DNA but are absent from the patient’s healthy cells. While some cancers may also ...

A combined whole-genome sequencing approach could be used to detect and monitor cancer from liquid biopsies. It is challenging to monitor cancer from liquid biopsies due to the low concentrations of ...