Medical Xpress

TP53 gene mutations affect lung cancer treatment response, study shows

Lung cancer is the most common and deadly form of cancer worldwide. It is increasingly understood to be a complex genetic disease with different mutations that vary according to factors such as ...
Medical Xpress

New mutations in TP53 gene drive resistance to p53-targeted cancer therapy

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...
Nature

KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma

Predictive biomarkers in use for immunotherapy in advanced non-small cell lung cancer are of limited sensitivity and specificity. We analysed the potential of activating KRAS and pathogenic TP53 ...
Nature

TP53 deficiency in AML induces resistance to T-cell engagers through an immunosuppressive secretome

T cells from healthy donors (HDs) and AML patients were isolated from peripheral blood mononuclear cells (PBMCs) using a PAN T-cell Isolation Kit (Miltenyi Biotec) or the EasySep Human CD2 Positive ...
The University of Chicago Chronicle

Mutant gene behind aggressive adult leukemia offers new clues for treatment

Imagine a tiny superhero inside every cell of your body whose job is to stop damaged cells before they turn dangerous. That superhero is a gene called TP53, and for decades scientists have known it as ...