Merck and Moderna announced on August 19 that their personalized mRNA cancer vaccine, intismeran autogene, did something cancer immunologists have been waiting nearly a decade to see: it beat ...

Personalized mRNA vaccines are enabling long-term remission in some stage II pancreatic cancer patients by reprogramming the ...

When an individual is born with genetic defects, there are a few ways to deal with the impact of the faulty genes. The most extreme solution is direct DNA editing to repair the mutation, while the ...

Some genetic mutations that are expected to completely stop a gene from working surprisingly cause only mild or even no symptoms. Researchers in previous studies have discovered one reason why: cells ...

・tRNA-based treatments are a promising approach for genetic diseases caused by nonsense mutations. ・Cystic fibrosis can sometimes be caused by nonsense mutations that stop a key protein being formed ...

Merck and Moderna’s new personalized cancer vaccine paired with the standard of care reduced the risk of recurrence and death ...

The INTerpath-009 trial will investigate an individualized neoantigen therapy plus Keytruda in patients with non-small cell lung cancer post-surgery whose disease didn't fully respond to prior ...

Researchers at Monash University in Melbourne, Australia, have uncovered the hidden code governing how genetic mutations affect RNA splicing and result in disease. The researchers were able to ...

A new review finds that mRNA vaccines and host-directed therapeutics for multidrug-resistant ESKAPE bacteria remain ...