EurekAlert!

Functional impact of DNMT3B knockout on DNA methylation, gene expression, and drug sensitivity in M07e cells. (IMAGE)

(A) Schematic representation of the CRISPR-Cas9-mediated knockout of DNMT3B (DNMT3B KO) in M07e cells. The U6 promoter drives expression of an hDNMT3B-targeting single-guide RNA (sgRNA), while an EFS ...
Nature

The Role of Methylation in Gene Expression

Not all genes are active at all times. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression. This straightforward experiment demonstrated that it was not ...
EurekAlert!

Detection and extraction of similar features in the disease-related gene groups

After converting Gene expression profile, DNA methylation profile, SNP profile into line of the subject participants’ square through linear kernelization to each, extract the subject pattern through ...
MarketWatch

SynGenSys Introduces Liver.SET Synthetic Promoter Library for Liver-specific Gene Expression for in vivo Gene Therapies

SynGenSys, a biotechnology company designing synthetic gene promoter systems to address critical bottlenecks in biopharma manufacturing and enhance cell and gene therapy development, today announced ...
Mayo Clinic

Epigenetic studies in Alzheimer's disease and other conditions

Learn about epigenetic studies related to Alzheimer's disease in Mayo Clinic's Precision Medicine in Neurodegeneration Lab led by Nilufer Ertekin-Taner, M.D., Ph.D.
News Medical

The association between neighborhood deprivation, DNA methylation, and gene expression in breast tissue for Black and White women with breast cancer

Despite advances in breast cancer treatment reducing mortality across all racial and ethnic groups, Black women face a 40% higher death rate than White women. Socioeconomic disparities, notably in ...
Medical Xpress

Epigenetic changes regulate gene expression, but what regulates epigenetics?

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...
News Medical

Scientists reveal how DNA methylation drives astrocytes to become stem cells, unlocking new potential for brain repair

Astrocytes shed their supportive role and unlock hidden neurogenic potential, offering new hope for brain injury recovery through cutting-edge epigenetic reprogramming. Study: DNA methylation controls ...
Mayo Clinic

Gene expression studies in progressive supranuclear palsy

Learn about gene expression studies in progressive supranuclear palsy in Mayo Clinic's Precision Medicine in Neurodegeneration Lab led by Nilufer Ertekin-Taner, M.D., Ph.D.

New study offers insight into tissue-specific gene regulation of sheep

Livestock breeders could soon have more tools to improve the health and quality of their animals, thanks to a recent study ...
Morningstar

SynGenSys Introduces Liver.SET Synthetic Promoter Library for Liver-specific Gene Expression for in vivo Gene Therapies

Validated, tissue-specific library enables customisable and controllable liver-targeted gene expression with high specificity and minimal off-target activity in muscle tissue SynGenSys, a ...